PERSISTENT · TREATMENT-RESISTANT DEPRESSION
A treatment that is not helping enough
Get a second opinionabout your mental health
Understand what may be affecting your mental health and what options could be worth exploring next.
18+ · Educational, not diagnostic · Developed with Alexander Lebedev, MD, PhD
HOW IT WORKS
Three stepsat your own pace
Answer the questionnaireReceive your resultsExplore the Mental Health Guide
Complete the questionnaire to receive the Mental Health Guide, with relevant topics highlighted based on what you share.
Before you begin
Are you 18 or older?
Who this is for
People usually arrivewith one of these
KETAMINE · SPRAVATO
It worked before It doesn't anymore
Burnout · High responsibility
You keep functioning, but something in you done
Life transition · Loss of meaning
You're between versions of yourself
Inner work · Self-exploration
You're doing the work, you want structured way
For loved ones
You're looking for someone you care about
Prior psychedelic experience · Seeking structure
You've done this before. This is about doing it with medical support
WHY THIS GUIDE
Mental Health Guidein plain language
Full range of options
Lifestyle, therapy, medication and emerging treatments
Evidence made clear
See how strongly each approach is supported by research
Shaped by your answers
Your answers highlight relevant sections, not treatment recommendations
The person behind the test
Dr Alexander Lebedev, MD, PhD
Psychiatrist and neuroscientist. Leadership and teaching roles at European universities. 21 years of clinical practice. 300+ published papers.
This assessment was built by a psychiatrist who specialised exactly on the situations you're describing. The cases where the usual approaches ran out. It helped to 100+ people already, see if it'll work out for your situation.
About ONCE
A clearer viewof what to do next
ONCE is a professionally supported programme in Amsterdam. If you want to learn about our approach before or after the test, visit our page.